Detalhe da pesquisa
1.
LipidSIM: Inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, Markov modeling framework.
Metab Eng
; 82: 110-122, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38311182
2.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417625
3.
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Nucleic Acids Res
; 49(4): 1828-1839, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33544849
4.
Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review.
Alzheimers Dement
; 19(12): 5885-5904, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37563912
5.
CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.
J Neurol Neurosurg Psychiatry
; 93(5): 481-490, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35135868
6.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 48(4): 1691-1700, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980820
7.
Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.
Neuroimage
; 229: 117749, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33454416
8.
Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design.
J Neurol Neurosurg Psychiatry
; 92(12): 1271-1277, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344790
9.
Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle.
Nucleic Acids Res
; 47(12): 6029-6044, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31127296
10.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
Nucleic Acids Res
; 47(11): 5465-5479, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034558
11.
Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates.
Nucleic Acids Res
; 47(12): 6045-6058, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31076766
12.
In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer's disease.
J Neurol Neurosurg Psychiatry
; 2020 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32917821
13.
Construct validity of the Visual Cognitive Assessment Test (VCAT)-a cross-cultural language-neutral cognitive screening tool.
Int Psychogeriatr
; 32(1): 141-149, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31111797
14.
Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson's disease.
J Neurol Neurosurg Psychiatry
; 90(6): 681-687, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30683708
15.
Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.
Nucleic Acids Res
; 45(5): 2294-2306, 2017 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28158620
16.
Serious infection risk after 1 year between patients with rheumatoid arthritis treated with rituximab or with a second TNFi after initial TNFi failure: results from The British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.
Rheumatology (Oxford)
; 57(9): 1533-1540, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28968862
17.
Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.
Bioorg Med Chem Lett
; 28(23-24): 3774-3779, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30342955
18.
Risk of lymphoma in patients exposed to antitumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.
Ann Rheum Dis
; 76(3): 497-503, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27502891
19.
Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis.
Ann Rheum Dis
; 76(4): 654-660, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28073800
20.
Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.
Bioorg Med Chem Lett
; 26(15): 3690-3, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27268307